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ECRG4: a new potential target in precision medicine
Xin Qin, Ping Zhang
《医学前沿(英文)》 2019年 第13卷 第5期 页码 540-546 doi: 10.1007/s11684-018-0637-9
关键词: ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis
Discovery of small molecule degraders for modulating cell cycle
《医学前沿(英文)》 页码 823-854 doi: 10.1007/s11684-023-1027-5
Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 128-135 doi: 10.1007/s11705-021-2080-8
Recent advances of small-molecule fluorescent probes for detecting biological hydrogen sulfide
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 34-63 doi: 10.1007/s11705-021-2050-1
关键词: hydrogen sulfide fluorescent probe reducibility nucleophilicity copper sulfide precipitate hydrogen polysulfides
《化学科学与工程前沿(英文)》 2023年 第17卷 第9期 页码 1208-1220 doi: 10.1007/s11705-023-2304-1
关键词: molecular synergy pseudocapacitive lignosulfonate flexible electronic devices asymmetric supercapacitor wide voltage windows
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening
Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 15-26 doi: 10.1007/s11705-017-1629-z
关键词: biosensor small molecule product transcription factor riboswitch high-throughput screening
Xiaowei LUO, Yannick BENICHOU, Suyuan YU
《能源前沿(英文)》 2013年 第7卷 第4期 页码 506-510 doi: 10.1007/s11708-013-0275-5
关键词: aerosol particles collision frequency function coagulation
Application progress of lymphography in oncology
Yang YU, Jibin LIU, Lixue YIN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 13-19 doi: 10.1007/s11684-009-0016-7
关键词: lymphography lymphatic metastasis sentinel lymph node biopsy
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 449-461 doi: 10.1007/s11684-017-0589-5
In recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging viruses have become more frequent, which is possibly due to environmental changes. These outbreaks result in the loss of life and economic hardship. Vaccines and therapeutics should be developed for the prevention and treatment of infectious diseases. In this review, we summarize and discuss the latest progress in the development of small-molecule viral inhibitors against highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, Ebola virus, and Zika virus. These viruses can interfere with the specific steps of viral life cycle by blocking the binding between virus and host cells, disrupting viral endocytosis, disturbing membrane fusion, and interrupting viral RNA replication and translation, thereby demonstrating potent therapeutic effect against various emerging and re-emerging viruses. We also discuss some general strategies for developing small-molecule viral inhibitors.
关键词: emerging and re-emerging viruses small-molecule inhibitor coronavirus Ebola virus Zika virus life cycle
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
《医学前沿(英文)》 doi: 10.1007/s11684-023-1037-3
Vaibhav Mundra, Ram I. Mahato
《化学科学与工程前沿(英文)》 2014年 第8卷 第4期 页码 387-404 doi: 10.1007/s11705-014-1457-3
关键词: nanocarrier cellular uptake endosomal release nucleic acid drug
陈景
《中国工程科学》 2003年 第5卷 第6期 页码 39-43
氢原子中1 s电子的电子云呈球形,电子的最大几率密度分布出现在玻尔半径a0的球壳内,认为几率密度分布及电子云属统计规律,意味着已经使用了宏观时标,这样就使氢分子体系中能量和时间的作用量远大于普郎克常数;根据电子云的交叠,用经典力学计算了基态氢分子的结构常数,获得键长、键能及力常数的表达式分别为Re = 〓a0,De = ze/4〓a0,k = ze/2〓,采用原子单位(a.u.)时z、e及a0均为1,获得Re=1.414 a.u.,De=0.177 a.u.,k=0.354 a.u.,这些数值与实验值的相对误差分别<1%,<2%和<4%;成键模型直观,物理意义明确,计算中不含任何人为性参数。
《医学前沿(英文)》 2023年 第17卷 第2期 页码 275-289 doi: 10.1007/s11684-022-0945-y
关键词: epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted therapy cisplatin
Qi Chen1 , Cen Zhang1 , Lingwei Xue1,2 , Zhi-Guo Zhang1
《化学科学与工程前沿(英文)》 2022年 第16卷 第10期 页码 1526-1529 doi: 10.1007/s11705-022-2161-3
Yongqing Zhou, Xin Wang, Wei Zhang, Bo Tang, Ping Li
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 4-33 doi: 10.1007/s11705-021-2041-2
关键词: bioactive molecules fluorescent probes in living cells and in vivo review
标题 作者 时间 类型 操作
A pseudocapacitive molecule-induced strategy to construct flexible high-performance asymmetric supercapacitors
期刊论文
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening
Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang
期刊论文
Calculation of collision frequency function for aerosol particles in free molecule regime in presence
Xiaowei LUO, Yannick BENICHOU, Suyuan YU
期刊论文
Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging
null
期刊论文
Design of nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic
Vaibhav Mundra, Ram I. Mahato
期刊论文
A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal
期刊论文
Bright future of polymerizing small-molecule acceptors in realizing high performance all-polymer solar
Qi Chen1 , Cen Zhang1 , Lingwei Xue1,2 , Zhi-Guo Zhang1
期刊论文